No effect of sinus rhythm restoration on hypercoagulability

Anja Wiedswang Horjen

Sustained sinus rhythm for six months after electrical cardioversion for atrial fibrillation had no impact on prothrombotic markers, network member Anja W. Horjen and co-authors conclude in an article published in Thrombosis Journal.

Furthermore, successfully cardioverted patients still in sinus rhythm after 6 months had significantly higher levels of D-dimer and prothrombin fragment 1+2 in atrial fibrillation than subjects without atrial fibrillation.

The results suggest that there is persistent hypercoagulability in atrial fibrillation patients despite successful cardioversion and long-term maintenance of sinus rhythm.

The findings also support current guidelines recommending continued anticoagulation after successful cardioversion in patients with risk factors for stroke.

Horjen AW, Seljeflot I, Berge T, Smith P, Arnesen H and Tveit A. Effect of sinus rhythm restoration on markers of thrombin generation in atrial fibrillation. Thrombosis Journal (2017) 15:30. DOI 10.1186/s12959-017-0153-1.

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