Assessment of the Relationship Between Genetic Determinants of Thyroid Function and Atrial Fibrillation – A Mendelian Randomization Study
“This mendelian randomization study of 55 114 individuals with AF and 482 295 referents found that genetically increased FT3:FT4 ratio and hyperthyroidism were associated with increased risk of AF, and thyrotropin within the reference range and hypothyroidism were inversely associated with risk of AF. There was no support for a direct involvement of FT4 within the reference range or thyroid peroxidase antibody levels in AF.
Meaning: Low thyrotropin, as an early sign of an overactive thyroid gland, with a concomitant increased FT3:FT4 ratio are genetically associated with AF.”
Christina Ellervik, MD, PhD, MSci, DMSci1,2,3; Carolina Roselli, MSci4; Ingrid E. Christophersen, MD, PhD5,6; et al.