Genetic variants associated with abnormal atrial activation

Several network members co-authored a recent article in Annals of Noninvasive Electrocardiology on the association between two genetic variants and altered P-wave morphology, reflecting abnormal atrial conduction. The same genetic variants, rs3807989 (CAV1/CAV2) and rs11047543 (SOX5), have previously been associated with PR‐interval prolongation and atrial fibrillation. Combined, these results suggest a biological link between common genetic variants and atrial fibrillation pathophysiology.

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